Patient-derived xenograft (PDX) models in basic and translational breast cancer research
نویسندگان
چکیده
منابع مشابه
Patient-Derived Xenograft (PDX) Models: An Emerging Platform for Cancer Drug Development and Translational Research
Previously, cancer drug development was an arena that relied almost exclusively on transgenic and severely compromised immuno-deficient (SCID) mice to measure tumor growth in response to novel therapeutic drugs. Development has now evolved to the point where several different murine models are now employed. The industry has expanded to include syngeneic and humanized mice, in addition to PDX mo...
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Despite the advancement of clinical and preclinical research on PCa, which resulted in the last five years in a decrement of disease incidence by 3-4%, it remains the most frequent cancer in men and the second for mortality rate. Based on this evidence we present a brief dissertation on numerous preclinical models, comparing their advantages and disadvantages; among this we report the PDX mouse...
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Bone metastasis is a complex process that needs to be better understood in order to help clinicians prevent and treat it. Xenografts using patient-derived material (PDX) rather than cancer cell lines are a novel approach that guarantees more clinically realistic results. A primary culture of bone metastasis derived from a 67-year-old patient with breast cancer was cultured and then injected int...
متن کاملPatient-derived xenograft models: an emerging platform for translational cancer research.
UNLABELLED Recently, there has been an increasing interest in the development and characterization of patient-derived tumor xenograft (PDX) models for cancer research. PDX models mostly retain the principal histologic and genetic characteristics of their donor tumor and remain stable across passages. These models have been shown to be predictive of clinical outcomes and are being used for precl...
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AIM To assess the viability of orthotopic and heterotopic patient-derived pancreatic cancer xenografts implanted into nude mice. METHODS This study presents a prospective experimental analytical follow-up of the development of tumours in mice upon implantation of human pancreatic adenocarcinoma samples. Specimens were obtained surgically from patients with a pathological diagnosis of pancreat...
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ژورنال
عنوان ژورنال: Cancer and Metastasis Reviews
سال: 2016
ISSN: 0167-7659,1573-7233
DOI: 10.1007/s10555-016-9653-x